On 11 October, a Boeing 747-4H6(LCF) Dreamlifter (registered N718BA and operated by Atlas Air) departed Taranto-Grottaglie Airport, Italy carrying Dreamliner components towards Charleston Airport, United States.
During take-off, however, the aircraft lost a tire of the main landing gear. At moment of writing, flight 5Y4231 continues flying towards Charleston Airport.
The following footage appeared on social media:
https://twitter.com/BoardingPassRO/status/1579858165407305728